94-44-0

_96%

反應條件：

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene , Thiazolium, 4-methyl-3-(2,4,6-trimethylphenyl)-, salt with 1,1,1-trifluoro-N-[(t… Solvents: Dimethyl sulfoxide , Tetrahydrofuran ; rt

參考文獻：

N-Heterocyclic Carbene-Mediated Oxidative Electrosynthesis of Esters in a Microflow Cell

Green, Robert A.; Pletcher, Derek; Leach, Stuart G.; Brown, Richard C. D., Organic Letters, 2015, 17(13), 3290-3293

合成路線(xiàn)：1 步

108-88-3

_90%

反應條件：

1.1 Reagents: tert-Butyl hydroperoxide Catalysts: Titanium (superoxide) Solvents: Toluene ; 25 °C; 6 - 10 h, 80 °C

參考文獻：

Novel single-step esterification of aldehydes using a heterogeneous catalyst

, World Intellectual Property Organization, , ,

合成路線(xiàn)：1 步

100-54-9

_97%

反應條件：

1.1 Reagents: Hydrochloric acid Solvents: Dichloromethane , Benzyl alcohol ; 30 - 40 °C
1.2 Reagents: Sodium hydroxide Solvents: Dichloromethane , Water ; neutralized

參考文獻：

Preparation of nicotinate compounds

, China, , ,

合成路線(xiàn)：1 步

100-44-7

54-86-4

_93%

反應條件：

1.1 Solvents: Dimethyl sulfoxide , 1,3-Dibutylimidazolium bromide ; 12 min, 30 °C

參考文獻：

A rapid and facile esterification of Na-carboxylates with alkyl halides promoted by the synergy of the combined use of DMSO and an ionic liquid under ambient conditions

Dighe, Satish N.; Bhattad, Ravindra V.; Kulkarni, Raghunath R.; Jain, Kishor S.; Srinivasan, Kumar V., Synthetic Communications, 2010, 40(23), 3522-3527

合成路線(xiàn)：1 步

16837-38-0

_92%

反應條件：

1.1 Solvents: Pyridine

參考文獻：

The use of a nicotinoyl group as a protective group for hydroxyl and amino functions

Ushida, Satoshi, Chemistry Letters, 1989, (1), 59-60

合成路線(xiàn)：1 步

108-88-3

_90%

反應條件：

1.1 Reagents: tert-Butyl hydroperoxide Catalysts: Titanium superoxide (Ti(O2)2) Solvents: Decane ; rt; 6 h, 80 °C

參考文獻：

Titanium superoxide - a stable recyclable heterogeneous catalyst for oxidative esterification of aldehydes with alkylarenes or alcohols using TBHP as an oxidant

Dey, Soumen; Gadakh, Sunita K.; Sudalai, A., Organic & Biomolecular Chemistry, 2015, 13(43), 10631-10640

合成路線(xiàn)：1 步

100-54-9

_99%

反應條件：

1.1 Reagents: Water Catalysts: Ceria ; 24 h, 160 °C

參考文獻：

CeO2-catalyzed one-pot selective synthesis of esters from nitriles and alcohols

Tamura, Masazumi; Tonomura, Takuya; Shimizu, Ken-ichi; Satsuma, Atsushi, Green Chemistry, 2012, 14(4), 984-991

合成路線(xiàn)：1 步

_94%

反應條件：

1.1 Reagents: Diethylene glycol Catalysts: 2-Propanol, lanthanum(3+) salt Solvents: Hexane ; 1 h, rt
1.2 rt → 90 °C; 2 h, 90 °C

參考文獻：

Lanthanum complexes, their uses as ester synthesis catalysts, and preparation of esters by transesterification using the complexes or lanthanum alkoxides and ligands

, Japan, , ,

合成路線(xiàn)：1 步

3468-53-9

_92%

反應條件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; 2 h, 70 °C

參考文獻：

Carbonylation of Aryl Chlorides with Oxygen Nucleophiles at Atmospheric Pressure. Preparation of Phenyl Esters as Acyl Transfer Agents and the Direct Preparation of Alkyl Esters and Carboxylic Acids

Watson, Donald A.; Fan, Xuexiang; Buchwald, Stephen L., Journal of Organic Chemistry, 2008, 73(18), 7096-7101

合成路線(xiàn)：1 步

54-86-4

_91%

反應條件：

1.1 Reagents: Triethylamine , 1-(p-Toluenesulfonyl)imidazole Catalysts: Tetrabutylammonium iodide Solvents: Dimethylformamide ; 3 h, reflux

參考文獻：

A simple procedure for the esterification of alcohols with sodium carboxylate salts using 1-tosylimidazole (TsIm)

Soltani Rad, Mohammad Navid; Behrouz, Somayeh; Faghihi, Mohammad Ali; Khalafi-Nezhad, Ali, Tetrahedron Letters, 2008, 49(7), 1115-1120

合成路線(xiàn)：1 步

_89%

反應條件：

1.1 Reagents: Potassium acetate , Trichloroacetonitrile Catalysts: 5H-Pyrrolo[2,1-c]-1,2,4-triazolium, 6,7-dihydro-2-(2,4,6-trimethylphenyl)-, tetr… Solvents: tert-Butyl methyl ether ; 32 h, rt

參考文獻：

Carbene-catalyzed oxidative acylation promoted by an unprecedented oxidant CCl3CN

Wu, Zijun; Jiang, Di; Wang, Jian, Organic Chemistry Frontiers, 2019, 6(5), 688-693

合成路線(xiàn)：1 步

_81%

反應條件：

1.1 Reagents: Triethylamine Solvents: Dimethylformamide ; 1 d, 83 °C

參考文獻：

2-Benzyloxy-1-methylpyridinium trifluoromethanesulfonate

Dudley, Gregory B., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2008, 1, 1-2

合成路線(xiàn)：1 步

_96%

反應條件：

1.1 Catalysts: Trioctylphosphine , Lanthanum nitrate hexahydrate Solvents: Dimethyl carbonate ; 1 - 2 min, rt; rt → 110 °C; 1 h, 110 °C; 110 °C → rt
1.2 Solvents: Hexane ; rt → 90 °C; 6 h, 90 °C; 90 °C → rt
1.3 Reagents: Water ; 5 min, rt

參考文獻：

Preparation of esters by transesterification using lanthanum nitrate and phosphines or phosphonium quaternary ammonium alkyl carbonates

, Japan, , ,

合成路線(xiàn)：1 步

_96%

反應條件：

1.1 Catalysts: 1,3-Dicyclohexyl-1,3-dihydro-2H-imidazol-2-ylidene Solvents: Tetrahydrofuran ; 15 min, rt

參考文獻：

Efficient Transesterification/Acylation Reactions Mediated by N-Heterocyclic Carbene Catalysts

Grasa, Gabriela A.; Gueveli, Tatyana; Singh, Rohit; Nolan, Steven P., Journal of Organic Chemistry, 2003, 68(7), 2812-2819

合成路線(xiàn)：1 步

_92%

反應條件：

1.1 Catalysts: Lanthanum nitrate , Phosphonium, methyltrioctyl-, methyl carbonate (1:1) Solvents: Hexane ; 5 min, rt
1.2 1 h, 90 °C; 90 °C → rt
1.3 Reagents: Water ; 5 min, rt

參考文獻：

In situ generated "lanthanum(III) nitrate alkoxide" as a highly active and nearly neutral transesterification catalyst

Hatano, Manabu; Kamiya, Sho; Ishihara, Kazuaki, Chemical Communications (Cambridge, 2012, 48(76), 9465-9467

合成路線(xiàn)：1 步

31139-36-3

98-98-6

_91%

反應條件：

1.1 Catalysts: Magnesium perchlorate Solvents: Nitromethane ; overnight, 40 °C

參考文獻：

Lewis acids as highly efficient catalysts for the decarboxylative esterification of carboxylic acids with dialkyl dicarbonates

Goossen, L.; Doehring, A., Advanced Synthesis & Catalysis, 2003, 345(8), 943-947

合成路線(xiàn)：1 步

59-67-6

_86%

反應條件：

1.1 Catalysts: Oxobis(2,4-pentanedionato-κO2,κO4)titanium Solvents: Toluene ; 2 min, rt → 160 °C; 1 h, 160 °C

參考文獻：

Titanium-catalyzed esterification and transesterification reactions facilitated using microwave heating

Devine, William G.; Leadbeater, Nicholas E.; Jacob, Linda A., Future Medicinal Chemistry, 2010, 2(2), 225-230

合成路線(xiàn)：1 步

100-44-7

59-67-6

_86%

反應條件：

1.1 Reagents: Cesium carbonate Solvents: N-Methyl-2-pyrrolidone
1.2 Reagents: Trifluoroacetic acid Solvents: Dichloromethane

參考文獻：

High-speed couplings and cleavages in microwave-heated, solid-phase reactions at high temperatures

Stadler, Alexander; Kappe, C. Oliver, European Journal of Organic Chemistry, 2001, (5), 919-925

合成路線(xiàn)：1 步

1345837-77-5

_82%